Polynucleotides: The Next-Gen Regenerative Treatment for Skin & Hair

Polynucleotides (PNs) are the latest biotechnological breakthrough in aesthetic medicine, known for their ability to repair, regenerate, and revitalize the skin at a cellular level. Unlike traditional anti-aging treatments, PNs work by boosting skin fibroblast activity, enhancing tissue repair, and deeply hydrating the skin.

1. What Are Polynucleotides?

• Polynucleotides are chains of nucleotides (DNA & RNA fragments) that act as biostimulators, enhancing cellular repair and collagen synthesis.
• They are derived mainly from salmon or trout DNA, which is highly compatible with human skin.
• Function as powerful antioxidants, reducing oxidative stress and inflammation.

2. How Polynucleotides Work for Skin Rejuvenation

• Increase fibroblast proliferation, leading to higher collagen and elastin production.
• Improve extracellular matrix remodeling, resulting in firmer, plumper skin.
• Enhance deep hydration, making them ideal for dry, damaged, or aging skin.
• Have anti-inflammatory and wound-healing properties, beneficial for sensitive, rosacea-prone, or post-procedure skin.

3. Clinical Benefits of Polynucleotides

• Anti-Aging & Wrinkle Reduction: Stimulates collagen types I & III, improving skin texture and elasticity.
• Post-Laser & Post-Procedure Healing: Polynucleotide-based serums accelerate recovery from laser, microneedling, and chemical peels.
• Acne Scar Treatment: Enhances skin regeneration, improving acne scars and post-inflammatory hyperpigmentation (PIH).
• Rosacea & Sensitive Skin: Reduces vascular inflammation and strengthens the skin barrier.

4. Polynucleotides for Hair Regrowth

• Stimulate hair follicle stem cells, increasing hair density and thickness.
• Improve scalp microcirculation, delivering more oxygen and nutrients to follicles.
• A 2023 study in the Journal of Dermatologic Therapy found that polynucleotide scalp injections increased hair count by 35% in 16 weeks.
• Work well in combination with PRP (Platelet-Rich Plasma) for enhanced results.

5. How to Incorporate Polynucleotides in Aesthetic Treatments

• Injectable Polynucleotides: Used in mesotherapy or microinjections for deep skin rejuvenation.
• Polynucleotide Serums & Creams: Ideal for daily skin barrier support and hydration.
• Combination Treatments: Work well with microneedling, PRP, and laser therapy for enhanced results.

Conclusion

Polynucleotides are revolutionizing skin and hair treatments, offering deep tissue regeneration, hydration, and cellular renewal. With scientific backing and clinical success, they are set to become a cornerstone of modern aesthetic medicine.